Chapter title |
The role of Mammalian sirtuins in the regulation of metabolism, aging, and longevity.
|
---|---|
Chapter number | 7 |
Book title |
Histone Deacetylases: the Biology and Clinical Implication
|
Published in |
Handbook of experimental pharmacology, January 2011
|
DOI | 10.1007/978-3-642-21631-2_7 |
Pubmed ID | |
Book ISBNs |
978-3-64-221630-5, 978-3-64-221631-2
|
Authors |
Akiko Satoh, Liana Stein, Shin Imai, Satoh, Akiko, Stein, Liana, Imai, Shin |
Abstract |
Ever since the discovery of sirtuins a decade ago, interest in this family of NAD-dependent deacetylases has exploded, generating multiple lines of evidence implicating sirtuins as evolutionarily conserved regulators of lifespan. In mammals, it has been established that sirtuins regulate physiological responses to metabolism and stress, two key factors that affect the process of aging. Further investigation into the intimate connection among sirtuins, metabolism, and aging has implicated the activation of SIRT1 as both preventative and therapeutic measures against multiple age-associated disorders including type 2 diabetes and Alzheimer's disease. SIRT1 activation has clear potential to not only prevent age-associated diseases but also to extend healthspan and perhaps lifespan. Sirtuin activating compounds and NAD intermediates are two promising ways to achieve these elusive goals. |
X Demographics
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Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | <1% |
Malaysia | 1 | <1% |
Austria | 1 | <1% |
Unknown | 125 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 21 | 16% |
Researcher | 17 | 13% |
Student > Master | 15 | 12% |
Student > Bachelor | 15 | 12% |
Other | 9 | 7% |
Other | 19 | 15% |
Unknown | 32 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 27 | 21% |
Medicine and Dentistry | 16 | 13% |
Agricultural and Biological Sciences | 16 | 13% |
Pharmacology, Toxicology and Pharmaceutical Science | 9 | 7% |
Neuroscience | 8 | 6% |
Other | 17 | 13% |
Unknown | 35 | 27% |