@JohnConstas @RamonaGorasciuc @Satyamjayatu1 Nicely written piece! A couple of points: (1) Liver is a metabolic system, not filtration like kidney. (2) the major drug/xenobiotic detoxification or metabolism is not via classical mechanism, but occurs via th
CYPs are not activated by protein-protein interactions with CPR or Cyt. b5. They need not bind their substrate at the distal heme pocket. Diffusible reactive oxygen species (DROS) are not wastes in the milieu, the reaction goes obligatorily via DROS. See:
@theliverdr @Ayurved_Gurukul @theliverdr I am a well-wishing biochemist from Kerala (https://t.co/PHdMKXxylW), who wants you to attack only specific claims/practices of any institution you don't like. I also wanted your opinion on the murburn model of drug
@theliverdr Dr. Cyriac Abby Philips: How come rationality does not apply to cytochrome P450 mediated metabolic mechanism in the liver? I wrote to you about this several weeks back, no response yet! https://t.co/sKbEz407jp