Sonia Martínez-Herrero, Ignacio M. Larrayoz, Laura Ochoa-Callejero, Luis J. Fernández, Alexis Allueva, Ignacio Ochoa, Alfredo Martínez
Abstract
Despite recent advances in the understanding and treatment options for osteoporosis, this condition remains a serious public health issue. Adrenomedullin (AM) is a regulatory peptide with reported activity on bone remodeling. To better understand this relationship we built an inducible knockout for AM. An outstanding feature of knockout mice is their heavier weight due, in part, to the presence of denser bones. The femur of knockout animals was denser, had more trabeculae, and a thicker growth plate than wild type littermates. The endocrine influence of AM on bone seems to be elicited through an indirect mechanism involving, at least, the regulation of insulin, glucose, ghrelin, and calcitonin gene-related peptide (CGRP). To confirm the data we performed a pharmacological approach using the AM inhibitor 16311 in a mouse model of osteoporosis. Ovariectomized females showed significant bone mass loss, whereas ovariectomized females treated with 16311 had similar bone density to sham operated females. In conclusion, we propose the use of AM inhibitors for the treatment of osteoporosis and other conditions leading to the loss of bone mass.
Pharmacology, Toxicology and Pharmaceutical Science
1
7%
Sports and Recreations
1
7%
Other
1
7%
Unknown
4
29%
Attention Score in Context
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 July 2016.
All research outputs
#15,379,002
of 22,879,161 outputs
Outputs from Frontiers in Physiology
#6,701
of 13,671 outputs
Outputs of similar age
#222,762
of 351,542 outputs
Outputs of similar age from Frontiers in Physiology
#77
of 171 outputs
Altmetric has tracked 22,879,161 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,671 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one is in the 47th percentile – i.e., 47% of its peers scored the same or lower than it.
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We're also able to compare this research output to 171 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.
