Title |
Phytol-Derived Novel Isoprenoid Immunostimulants
|
---|---|
Published in |
Frontiers in immunology, January 2012
|
DOI | 10.3389/fimmu.2012.00049 |
Pubmed ID | |
Authors |
Roshni Roy Chowdhury, Swapan K. Ghosh |
Abstract |
This review describes the adjuvanticity of novel diterpenoids (synthetic phytol derivatives) compared to some commercially available adjuvants. The efficacy of the phytol-derived immunostimulants was evaluated in terms of their ability to activate innate immunity, amplify various antigen-specific immune responses, and engender immunological memory with no discernible adverse effects in both competent and immune-deficient mice. The profile that emerges out of these studies reveals that the phytol derivatives are excellent immunostimulants, superior to a number of commercial adjuvants in terms of long-term memory induction and activation of both innate and acquired immunity. Additionally, the phytol-derived compounds have no cumulative inflammatory or toxic effects even in immuno-compromised mice. |
X Demographics
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Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 45 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Doctoral Student | 7 | 16% |
Student > Ph. D. Student | 6 | 13% |
Researcher | 6 | 13% |
Student > Master | 6 | 13% |
Lecturer | 4 | 9% |
Other | 3 | 7% |
Unknown | 13 | 29% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 9 | 20% |
Agricultural and Biological Sciences | 7 | 16% |
Chemistry | 6 | 13% |
Chemical Engineering | 2 | 4% |
Immunology and Microbiology | 2 | 4% |
Other | 7 | 16% |
Unknown | 12 | 27% |