Title |
CXCR2: From Bench to Bedside
|
---|---|
Published in |
Frontiers in immunology, January 2012
|
DOI | 10.3389/fimmu.2012.00263 |
Pubmed ID | |
Authors |
Anika Stadtmann, Alexander Zarbock |
Abstract |
Leukocyte recruitment to sites of infection or tissue damage plays a crucial role for the innate immune response. Chemokine-dependent signaling in immune cells is a very important mechanism leading to integrin activation and leukocyte recruitment. CXC chemokine receptor 2 (CXCR2) is a prominent chemokine receptor on neutrophils. During the last years, several studies were performed investigating the role of CXCR2 in different diseases. Until now, many CXCR2 inhibitors are tested in animal models and clinical trials and promising results were obtained. This review gives an overview of the structure of CXCR2 and the signaling pathways that are activated following CXCR2 stimulation. We discuss in detail the role of this chemokine receptor in different disease models including acute lung injury, COPD, sepsis, and ischemia-reperfusion-injury. Furthermore, this review summarizes the results of clinical trials which used CXCR2 inhibitors. |
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Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | <1% |
France | 1 | <1% |
Unknown | 199 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 42 | 21% |
Student > Ph. D. Student | 38 | 19% |
Student > Master | 22 | 11% |
Student > Bachelor | 20 | 10% |
Student > Doctoral Student | 14 | 7% |
Other | 21 | 10% |
Unknown | 44 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 38 | 19% |
Medicine and Dentistry | 32 | 16% |
Immunology and Microbiology | 26 | 13% |
Biochemistry, Genetics and Molecular Biology | 23 | 11% |
Chemistry | 8 | 4% |
Other | 25 | 12% |
Unknown | 49 | 24% |