Mark T. W. Ebbert, Lyndsay A. Staley, Joshua Parker, Sheradyn Parker, Matthew Bailey, for the Alzheimer’s Disease Neuroimaging Initiative, Perry G. Ridge, Alison M. Goate, John S. K. Kauwe
Abstract
CCL16 is a chemokine predominantly expressed in the liver, but is also found in the blood and brain, and is known to play important roles in immune response and angiogenesis. Little is known about the gene's regulation.
Here, we test for potential causal SNPs that affect CCL16 protein levels in both blood plasma and cerebrospinal fluid in a genome-wide association study across two datasets. We then use METAL to performed meta-analyses with a significance threshold of p < 5x10(-8). We removed SNPs where the direction of the effect was different between the two datasets.
We identify 10 SNPs associated with increased CCL16 protein levels in both biological fluids.
Our results will help understand CCL16's regulation, allowing researchers to better understand the gene's effects on human health.
This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 July 2016.
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