The data shown below were collected from the profiles of 709 X users who shared this research output. Click here to find out more about how the information was compiled.
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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Mammalian lipid droplets are innate immune hubs integrating cell metabolism and host defense
|
|---|---|
| Published in |
Science, October 2020
|
| DOI | 10.1126/science.aay8085 |
| Pubmed ID | |
| Authors |
Marta Bosch, Miguel Sánchez-Álvarez, Alba Fajardo, Ronan Kapetanovic, Bernhard Steiner, Filipe Dutra, Luciana Moreira, Juan Antonio López, Rocío Campo, Montserrat Marí, Frederic Morales-Paytuví, Olivia Tort, Albert Gubern, Rachel M Templin, James E B Curson, Nick Martel, Cristina Català, Francisco Lozano, Francesc Tebar, Carlos Enrich, Jesús Vázquez, Miguel A Del Pozo, Matthew J Sweet, Patricia T Bozza, Steven P Gross, Robert G Parton, Albert Pol |
| Abstract |
Lipid droplets (LDs) are the major lipid storage organelles of eukaryotic cells and a source of nutrients for intracellular pathogens. We demonstrate that mammalian LDs are endowed with a protein-mediated antimicrobial capacity, which is up-regulated by danger signals. In response to lipopolysaccharide (LPS), multiple host defense proteins, including interferon-inducible guanosine triphosphatases and the antimicrobial cathelicidin, assemble into complex clusters on LDs. LPS additionally promotes the physical and functional uncoupling of LDs from mitochondria, reducing fatty acid metabolism while increasing LD-bacterial contacts. Thus, LDs actively participate in mammalian innate immunity at two levels: They are both cell-autonomous organelles that organize and use immune proteins to kill intracellular pathogens as well as central players in the local and systemic metabolic adaptation to infection. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 65 | 9% |
| Spain | 23 | 3% |
| United Kingdom | 19 | 3% |
| France | 15 | 2% |
| Australia | 10 | 1% |
| Japan | 7 | <1% |
| Canada | 7 | <1% |
| Germany | 6 | <1% |
| India | 6 | <1% |
| Other | 54 | 8% |
| Unknown | 497 | 70% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 394 | 56% |
| Scientists | 290 | 41% |
| Practitioners (doctors, other healthcare professionals) | 15 | 2% |
| Science communicators (journalists, bloggers, editors) | 9 | 1% |
| Unknown | 1 | <1% |
Mendeley readers
The data shown below were compiled from readership statistics for 528 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 528 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 92 | 17% |
| Researcher | 78 | 15% |
| Student > Master | 47 | 9% |
| Student > Bachelor | 44 | 8% |
| Student > Doctoral Student | 27 | 5% |
| Other | 83 | 16% |
| Unknown | 157 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 145 | 27% |
| Agricultural and Biological Sciences | 55 | 10% |
| Immunology and Microbiology | 54 | 10% |
| Medicine and Dentistry | 21 | 4% |
| Neuroscience | 16 | 3% |
| Other | 57 | 11% |
| Unknown | 180 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 697. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 September 2023.
All research outputs
#32,004
of 26,583,927 outputs
Outputs from Science
#1,363
of 84,224 outputs
Outputs of similar age
#1,182
of 441,505 outputs
Outputs of similar age from Science
#50
of 989 outputs
Altmetric has tracked 26,583,927 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 84,224 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 66.6. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 441,505 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 989 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.