Title |
Prognostic significance of circulating laminin gamma2 for early-stage non-small-cell lung cancer
|
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Published in |
OncoTargets and therapy, July 2016
|
DOI | 10.2147/ott.s105732 |
Pubmed ID | |
Authors |
Yu Teng, Zitong Wang, Li Ma, Lina Zhang, Yinan Guo, Meng Gu, Ziyu Wang, Yue Wang, Wentao Yue |
Abstract |
Laminin gamma2 (Ln-γ2) chain, a distinctive subunit of heterotrimeric laminin-332, is frequently upregulated in carcinomas and is of great importance in cell migration and invasion. Despite this, the status of circulating Ln-γ2 in lung cancer patients is still uncertain. In this retrospective study, serum samples from 538 all-stage (stages I-IV) patients with non-small-cell lung cancer (NSCLC) and 94 age-matched healthy volunteers were investigated by enzyme-linked immunosorbent assay. Data were statistically analyzed in combination with clinicopathological information. Circulating Ln-γ2 was markedly increased in NSCLC, even in stage I cases (P<0.01), reflecting the progression of lung cancer. Survival analysis on 370 eligible patients indicated that serum Ln-γ2-negative patients survived much longer compared with Ln-γ2-positive individuals (P=0.028), and it was especially the case for stage I (P<0.001), stage T1 (P=0.001), and stage N0 patients (P=0.038), all of whom represented early-stage cases. For the advanced patients, however, overall survivals were not significantly different among stages II-IV (P=0.830), stages T2-T4 (P=0.575), stages N1-N3 (P=0.669), and stage M1 (P=0.849). Cox analysis subsequently defined serum Ln-γ2 as an independent prognostic indicator of NSCLC, particularly for early-stage patients. Furthermore, we demonstrated the association of serum Ln-γ2 with smoking behavior, but its association with tumor progression and early prognostic significance were not altered in the nonsmoking cohort. Our study demonstrated that elevation of circulating Ln-γ2 was an early-emerging event in NSCLC and was significantly associated with poor prognosis in NSCLC, especially for early-stage cases. |
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Demographic breakdown
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Professor | 2 | 17% |
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Other | 2 | 17% |
Unknown | 2 | 17% |
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Other | 0 | 0% |
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