Lite ref-meterial kring M4 PAMs: https://t.co/VZZh25tHFj samt https://t.co/0OluMrsqdg
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This in depth review by #NeuroTPA @DrEmGPCRologist and the #ASNPlab @MIPS_Australia explores physiologically relevant muscarinic signalling pathways involved in neurodevelopmental & neurodegenerative disorders #TPATuesday https://t.co/duu43uGFHa
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Fine Tuning Muscarinic Acetylcholine Receptor Signaling Through Allostery and Bias https://t.co/LCHuEp3bqd One challenge is the potential for on-target side effects, such as for the M1 mAChR where over-activation of the receptor by orthosteric or alloster
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RT @raintank2010: One challenge is the potential for on-target side effects, such as for the M1 mAChR where over-activation of the receptor…