@EricTopol @PNASNews @GordFishell @Su_hang_ https://t.co/EaudLY8nWe demonstrates neuroinflammatory activation of oligodendrocytes without virions crossing the BBB. Crosstalk with astrocytes/microglia and subsequent neuronal injury is concerning. Further st
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Astrocyte–Oligodendrocyte–Microglia Crosstalk in Astrocytopathies https://t.co/G72v0ldJTX "In VWM, an excess of hyaluronan might inhibit TLR4-signaling in glia, thus limiting the production of cytokines and chemokines upon simulation by LPS"
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Astrocyte–Oligodendrocyte–Microglia Crosstalk in Astrocytopathies https://t.co/G72v0ldJTX "hyaluronic acid, which is abundantly expressed in VWM lesions, is a ligand for TLR2 and TLR4 (Termeer et al., 2002; Scheibner et al., 2006)."
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