Title |
On the interactions between mesenchymal stem cells and regulatory T cells for immunomodulation in transplantation
|
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Published in |
Frontiers in immunology, January 2012
|
DOI | 10.3389/fimmu.2012.00126 |
Pubmed ID | |
Authors |
Anja U. Engela, Carla C. Baan, Frank J. M. F. Dor, Willem Weimar, Martin J. Hoogduijn |
Abstract |
Experimental studies have established the use of mesenchymal stem cells (MSC) as a candidate immunosuppressive therapy. MSC exert their immunomodulatory function through the inhibition of CD4(+) and CD8(+) T cell proliferation. It is unknown whether MSC impair the immunosuppressive function of regulatory T cells (Treg). In vitro and in vivo studies suggest that MSC mediate their immunomodulatory effects through the induction of Treg. In this review we will focus on the interactions between MSC and Treg, and evaluate the consequences of these cellular interplays for prospective MSC immunotherapy in organ transplantation. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 1 | 1% |
Germany | 1 | 1% |
Unknown | 76 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 16 | 21% |
Student > Ph. D. Student | 13 | 17% |
Student > Bachelor | 10 | 13% |
Student > Master | 10 | 13% |
Student > Postgraduate | 6 | 8% |
Other | 11 | 14% |
Unknown | 12 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 24 | 31% |
Medicine and Dentistry | 14 | 18% |
Biochemistry, Genetics and Molecular Biology | 12 | 15% |
Immunology and Microbiology | 8 | 10% |
Neuroscience | 2 | 3% |
Other | 5 | 6% |
Unknown | 13 | 17% |