A Dipolar Cycloaddition Reaction To Access 6‑Methyl-4,5,6,7-tetrahydro‑1H‑[1,2,3]triazolo[4,5‑c]pyridines Enables the Discovery Synthesis and Preclinical Profiling of a P2X7 Antagonist Clinical Candidate
Christa C. Chrovian, Akinola Soyode-Johnson, Alexander A. Peterson, Christine F. Gelin, Xiaohu Deng, Curt A. Dvorak, Nicholas I. Carruthers, Brian Lord, Ian Fraser, Leah Aluisio, Kevin J. Coe, Brian Scott, Tatiana Koudriakova, Freddy Schoetens, Kia Sepassi, David J. Gallacher, Anindya Bhattacharya, Michael A. Letavic
Pharmacology, Toxicology and Pharmaceutical Science
7
14%
Agricultural and Biological Sciences
3
6%
Biochemistry, Genetics and Molecular Biology
2
4%
Arts and Humanities
2
4%
Other
7
14%
Unknown
17
35%
Attention Score in Context
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 June 2024.
All research outputs
#7,722,978
of 23,485,204 outputs
Outputs from Journal of Medicinal Chemistry
#12,992
of 22,331 outputs
Outputs of similar age
#154,122
of 443,153 outputs
Outputs of similar age from Journal of Medicinal Chemistry
#76
of 116 outputs
Altmetric has tracked 23,485,204 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 22,331 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.7. This one is in the 10th percentile – i.e., 10% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 443,153 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 54% of its contemporaries.
We're also able to compare this research output to 116 others from the same source and published within six weeks on either side of this one. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.
