Xiaona Du, Haixia Gao, David Jaffe, Hailin Zhang, Nikita Gamper
Abstract
Pathological pain is a hyperexcitability disorder. Since the excitability of a neuron is set and controlled by a complement of ion channels it expresses, in order to understand and treat pain we need to develop a mechanistic insight into the key ion channels controlling excitability within the mammalian pain pathways, and how these ion channels are regulated and modulated in various physiological and pathophysiological settings. In this review we will discuss the emerging data on the expression in pain pathways, functional role and modulation of a family of voltage-gated K(+) channels called 'M channels' (KCNQ, Kv7). M channels are increasingly recognised as important players in controlling pain signaling, especially within the peripheral somatosensory system. We will also discuss therapeutic potential of M channels as analgesic drug targets.
Pharmacology, Toxicology and Pharmaceutical Science
6
11%
Medicine and Dentistry
4
8%
Agricultural and Biological Sciences
3
6%
Other
3
6%
Unknown
20
38%
Attention Score in Context
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 September 2017.
All research outputs
#6,263,436
of 24,417,958 outputs
Outputs from British Journal of Pharmacology
#2,207
of 7,563 outputs
Outputs of similar age
#93,086
of 321,823 outputs
Outputs of similar age from British Journal of Pharmacology
#28
of 80 outputs
Altmetric has tracked 24,417,958 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 7,563 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one has gotten more attention than average, scoring higher than 70% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 321,823 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 80 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.
