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Aberrations of DNA Repair Pathways in Prostate Cancer: Future Implications for Clinical Practice?

Overview of attention for article published in Frontiers in Cell and Developmental Biology, September 2018
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Title
Aberrations of DNA Repair Pathways in Prostate Cancer: Future Implications for Clinical Practice?
Published in
Frontiers in Cell and Developmental Biology, September 2018
DOI 10.3389/fcell.2018.00071
Pubmed ID
Authors

Orazio Caffo, Antonello Veccia, Stefania Kinspergher, Mimma Rizzo, Francesca Maines

Abstract

Patients who are carriers of inherited mutations in essential component of DNA repair pathways have a significantly higher lifetime risk for developing cancer compared to the population of reference. Recent advances in DNA next-generation sequencing technology have allowed screening for carriers of those mutations, allowing development of promising risk-reduction strategies and providing the rationale to personalize the therapeutic approach for these patients. New intriguing scenarios are opening nowadays for the management of prostate cancer in patients with germline or somatic mutations in components of DNA repair pathways (e.g., BRCA1 and BRCA2 genes), such as specific screening policies and new therapeutic strategies involving PARP inhibitors or platinum-based chemotherapy.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 31 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 4 13%
Unspecified 3 10%
Researcher 3 10%
Other 2 6%
Student > Ph. D. Student 2 6%
Other 1 3%
Unknown 16 52%
Readers by discipline Count As %
Medicine and Dentistry 7 23%
Biochemistry, Genetics and Molecular Biology 4 13%
Unspecified 3 10%
Agricultural and Biological Sciences 1 3%
Immunology and Microbiology 1 3%
Other 1 3%
Unknown 14 45%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 September 2018.
All research outputs
#18,648,325
of 23,102,082 outputs
Outputs from Frontiers in Cell and Developmental Biology
#5,045
of 9,165 outputs
Outputs of similar age
#257,897
of 335,873 outputs
Outputs of similar age from Frontiers in Cell and Developmental Biology
#51
of 59 outputs
Altmetric has tracked 23,102,082 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 9,165 research outputs from this source. They receive a mean Attention Score of 3.4. This one is in the 32nd percentile – i.e., 32% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 335,873 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 59 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.