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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Detection of Collapse and Crystallization of Saccharide, Protein, and Mannitol Formulations by Optical Fibers in Lyophilization
|
|---|---|
| Published in |
Frontiers in Chemistry, January 2018
|
| DOI | 10.3389/fchem.2018.00004 |
| Pubmed ID | |
| Authors |
Jacqueline Horn, Wolfgang Friess |
| Abstract |
The collapse temperature (Tc) and the glass transition temperature of freeze-concentrated solutions (Tg') as well as the crystallization behavior of excipients are important physicochemical characteristics which guide the cycle development in freeze-drying. The most frequently used methods to determine these values are differential scanning calorimetry (DSC) and freeze-drying microscopy (FDM). The objective of this study was to evaluate the optical fiber system (OFS) unit as alternative tool for the analysis of Tc, Tg' and crystallization events. The OFS unit was also tested as a potential online monitoring tool during freeze-drying. Freeze/thawing and freeze-drying experiments of sucrose, trehalose, stachyose, mannitol, and highly concentrated IgG1 and lysozyme solutions were carried out and monitored by the OFS. Comparative analyses were performed by DSC and FDM. OFS and FDM results correlated well. The crystallization behavior of mannitol could be monitored by the OFS during freeze/thawing as it can be done by DSC. Online monitoring of freeze-drying runs detected collapse of amorphous saccharide matrices. The OFS unit enabled the analysis of both Tc and crystallization processes, which is usually carried out by FDM and DSC. The OFS can hence be used as novel measuring device. Additionally, detection of these events during lyophilization facilitates online-monitoring. Thus the OFS is a new beneficial tool for the development and monitoring of freeze-drying processes. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 98 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 98 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 16 | 16% |
| Student > Master | 10 | 10% |
| Researcher | 8 | 8% |
| Student > Doctoral Student | 7 | 7% |
| Student > Bachelor | 7 | 7% |
| Other | 7 | 7% |
| Unknown | 43 | 44% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 11 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 11 | 11% |
| Biochemistry, Genetics and Molecular Biology | 11 | 11% |
| Engineering | 5 | 5% |
| Agricultural and Biological Sciences | 4 | 4% |
| Other | 10 | 10% |
| Unknown | 46 | 47% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 January 2018.
All research outputs
#20,461,148
of 23,018,998 outputs
Outputs from Frontiers in Chemistry
#2,935
of 6,010 outputs
Outputs of similar age
#377,752
of 440,577 outputs
Outputs of similar age from Frontiers in Chemistry
#43
of 74 outputs
Altmetric has tracked 23,018,998 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 6,010 research outputs from this source. They receive a mean Attention Score of 2.0. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 74 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.