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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Cellular Tight Junctions Prevent Effective Campylobacter jejuni Invasion and Inflammatory Barrier Disruption Promoting Bacterial Invasion from Lateral Membrane in Polarized Intestinal Epithelial Cells
|
|---|---|
| Published in |
Frontiers in Cellular and Infection Microbiology, January 2018
|
| DOI | 10.3389/fcimb.2018.00015 |
| Pubmed ID | |
| Authors |
Sho Hatayama, Takaaki Shimohata, Sachie Amano, Junko Kido, Anh Q. Nguyen, Yuri Sato, Yuna Kanda, Aya Tentaku, Shiho Fukushima, Mutsumi Nakahashi, Takashi Uebanso, Kazuaki Mawatari, Akira Takahashi |
| Abstract |
Campylobacter jejuni invasion is closely related toC. jejunipathogenicity. The intestinal epithelium contains polarized epithelial cells that form tight junctions (TJs) to provide a physical barrier against bacterial invasion. Previous studies indicated thatC. jejuniinvasion of non-polarized cells involves several cellular features, including lipid rafts. However, the dynamics ofC. jejuniinvasion of polarized epithelial cells are not fully understood. Here we investigated the interaction betweenC. jejuniinvasion and TJ formation to characterize the mechanism ofC. jejuniinvasion in polarized epithelial cells. In contrast to non-polarized epithelial cells,C. jejuniinvasion was not affected by depletion of lipid rafts in polarized epithelial cells. However, depletion of lipid rafts significantly decreasedC. jejuniinvasion in TJ disrupted cells or basolateral infection and repair of cellular TJs suppressed lipid raft-mediatedC. jejuniinvasion in polarized epithelial cells. In addition, pro-inflammatory cytokine, TNF-α treatment that induce TJ disruption promoteC. jejuniinvasion and lipid rafts depletion significantly reducedC. jejuniinvasion in TNF-α treated cells. These data demonstrated that TJs preventC. jejuniinvasion from the lateral side of epithelial cells, where they play a main part in bacterial invasion and suggest thatC. jejuniinvasion could be increased in inflammatory condition. Therefore, maintenance of TJs integrity should be considered important in the development of novel therapies forC. jejuniinfection. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 44 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 44 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 9 | 20% |
| Researcher | 9 | 20% |
| Student > Ph. D. Student | 7 | 16% |
| Student > Master | 4 | 9% |
| Student > Doctoral Student | 3 | 7% |
| Other | 5 | 11% |
| Unknown | 7 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 10 | 23% |
| Biochemistry, Genetics and Molecular Biology | 9 | 20% |
| Immunology and Microbiology | 6 | 14% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 7% |
| Nursing and Health Professions | 2 | 5% |
| Other | 7 | 16% |
| Unknown | 7 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 January 2018.
All research outputs
#20,461,148
of 23,018,998 outputs
Outputs from Frontiers in Cellular and Infection Microbiology
#6,070
of 6,505 outputs
Outputs of similar age
#377,816
of 440,320 outputs
Outputs of similar age from Frontiers in Cellular and Infection Microbiology
#104
of 124 outputs
Altmetric has tracked 23,018,998 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 6,505 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.4. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 440,320 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 124 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.