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The smallest unit: effector and memory CD8+ T cell differentiation on the single cell level

Overview of attention for article published in Frontiers in immunology, January 2013
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  • Above-average Attention Score compared to outputs of the same age and source (57th percentile)

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Title
The smallest unit: effector and memory CD8+ T cell differentiation on the single cell level
Published in
Frontiers in immunology, January 2013
DOI 10.3389/fimmu.2013.00031
Pubmed ID
Authors

Veit R. Buchholz, Patricia Gräf, Dirk H. Busch

Abstract

CD8(+) T cell immune responses provide immediate protection against primary infection and durable memory capable of rapidly fighting off re-infection. Immediate protection and lasting memory are implemented by phenotypically and functionally distinct T cell subsets. While it is now widely accepted that these diverge from a common source of naïve T cells (T(n)), the developmental relation and succession of effector and memory T cell subsets is still under intense debate. Recently, a distinct memory T cell subset has been suggested to possess stem cell-like features, sparking the hope to harness its capacity for self-renewal and diversification for successful therapy of chronic infections or malignant diseases. In this review we highlight current developmental models of memory generation, T cell subset diversification and T cell stemness. We discuss the importance of single cell monitoring techniques for adequately mapping these developmental processes and take a brief look at signaling components active in the putative stem cell-like memory T cell compartment.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 97 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 1%
Czechia 1 1%
Australia 1 1%
Canada 1 1%
Unknown 93 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 33 34%
Researcher 20 21%
Student > Bachelor 8 8%
Student > Master 7 7%
Student > Doctoral Student 6 6%
Other 13 13%
Unknown 10 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 26 27%
Immunology and Microbiology 24 25%
Medicine and Dentistry 18 19%
Biochemistry, Genetics and Molecular Biology 5 5%
Psychology 3 3%
Other 10 10%
Unknown 11 11%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 February 2013.
All research outputs
#16,720,137
of 25,371,288 outputs
Outputs from Frontiers in immunology
#18,318
of 31,513 outputs
Outputs of similar age
#187,792
of 288,986 outputs
Outputs of similar age from Frontiers in immunology
#192
of 503 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 31,513 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one is in the 36th percentile – i.e., 36% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 288,986 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 33rd percentile – i.e., 33% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 503 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 57% of its contemporaries.