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Transcriptional Enhancers in the Regulation of T Cell Differentiation

Overview of attention for article published in Frontiers in immunology, September 2015
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Title
Transcriptional Enhancers in the Regulation of T Cell Differentiation
Published in
Frontiers in immunology, September 2015
DOI 10.3389/fimmu.2015.00462
Pubmed ID
Authors

Michelle L. T. Nguyen, Sarah A. Jones, Julia E. Prier, Brendan E. Russ

Abstract

The changes in phenotype and function that characterize the differentiation of naïve T cells to effector and memory states are underscored by large-scale, coordinated, and stable changes in gene expression. In turn, these changes are choreographed by the interplay between transcription factors and epigenetic regulators that act to restructure the genome, ultimately ensuring lineage-appropriate gene expression. Here, we focus on the mechanisms that control T cell differentiation, with a particular focus on the role of regulatory elements encoded within the genome, known as transcriptional enhancers (TEs). We discuss the central role of TEs in regulating T cell differentiation, both in health and disease.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 101 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 2 2%
Luxembourg 1 <1%
Unknown 98 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 21 21%
Student > Bachelor 18 18%
Researcher 17 17%
Student > Master 13 13%
Student > Doctoral Student 10 10%
Other 10 10%
Unknown 12 12%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 36 36%
Agricultural and Biological Sciences 21 21%
Immunology and Microbiology 12 12%
Medicine and Dentistry 6 6%
Nursing and Health Professions 3 3%
Other 11 11%
Unknown 12 12%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 September 2015.
All research outputs
#22,839,540
of 25,464,544 outputs
Outputs from Frontiers in immunology
#27,586
of 31,721 outputs
Outputs of similar age
#240,217
of 280,080 outputs
Outputs of similar age from Frontiers in immunology
#151
of 160 outputs
Altmetric has tracked 25,464,544 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 31,721 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 280,080 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 160 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.