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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Predominant Role of Plasmacytoid Dendritic Cells in Stimulating Systemic Autoimmunity
|
|---|---|
| Published in |
Frontiers in immunology, October 2015
|
| DOI | 10.3389/fimmu.2015.00526 |
| Pubmed ID | |
| Authors |
Xinfang Huang, Stephanie Dorta-Estremera, Yihong Yao, Nan Shen, Wei Cao |
| Abstract |
Plasmacytoid dendritic cells (pDCs), which are prominent type I interferon (IFN-I)-producing immune cells, have been extensively implicated in systemic lupus erythematosus (SLE). However, whether they participate critically in lupus pathogenesis remains unknown. Recent studies using various genetic and cell type-specific ablation strategies have demonstrated that pDCs play a pivotal role in the development of autoantibodies and the progression of lupus under diverse experimental conditions. The findings of several investigations highlight a notion that pDCs operate critically at the early stage of lupus development. In particular, pDCs have a profound effect on B-cell activation and humoral autoimmunity in vivo. This deeper understanding of the vital role of pDCs in lupus pathogenesis supports the therapeutic targeting of the pDC-IFN-I pathway in SLE. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Science communicators (journalists, bloggers, editors) | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 58 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 58 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 13 | 22% |
| Researcher | 10 | 17% |
| Student > Bachelor | 9 | 16% |
| Student > Doctoral Student | 4 | 7% |
| Other | 4 | 7% |
| Other | 9 | 16% |
| Unknown | 9 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 15 | 26% |
| Medicine and Dentistry | 10 | 17% |
| Biochemistry, Genetics and Molecular Biology | 9 | 16% |
| Agricultural and Biological Sciences | 7 | 12% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 5% |
| Other | 5 | 9% |
| Unknown | 9 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 November 2015.
All research outputs
#16,266,532
of 26,150,873 outputs
Outputs from Frontiers in immunology
#15,912
of 32,975 outputs
Outputs of similar age
#152,224
of 293,095 outputs
Outputs of similar age from Frontiers in immunology
#82
of 168 outputs
Altmetric has tracked 26,150,873 research outputs across all sources so far. This one is in the 36th percentile – i.e., 36% of other outputs scored the same or lower than it.
So far Altmetric has tracked 32,975 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.5. This one is in the 48th percentile – i.e., 48% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 293,095 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 168 others from the same source and published within six weeks on either side of this one. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.