Title |
Human αβ and γδ T Cells in Skin Immunity and Disease
|
---|---|
Published in |
Frontiers in immunology, June 2018
|
DOI | 10.3389/fimmu.2018.01304 |
Pubmed ID | |
Authors |
Michelle S. Cruz, Alani Diamond, Astrid Russell, Julie Marie Jameson |
Abstract |
γδ T lymphocytes maintain skin homeostasis by balancing keratinocyte differentiation and proliferation with the destruction of infected or malignant cells. An imbalance in skin-resident T cell function can aggravate skin-related autoimmune diseases, impede tumor eradication, or disrupt proper wound healing. Much of the published work on human skin T cells attributes T cell function in the skin to αβ T cells, while γδ T cells are an often overlooked participant. This review details the roles played by both αβ and γδ T cells in healthy human skin and then focuses on their roles in skin diseases, such as psoriasis and alopecia areata. Understanding the contribution of skin-resident and skin-infiltrating T cell populations and cross-talk with other immune cells is leading to the development of novel therapeutics for patients. However, there is still much to be learned in order to effectively modulate T cell function and maintain healthy skin homeostasis. |
X Demographics
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 22% |
Australia | 1 | 11% |
Unknown | 6 | 67% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 9 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 178 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 38 | 21% |
Researcher | 30 | 17% |
Student > Master | 19 | 11% |
Other | 12 | 7% |
Student > Bachelor | 12 | 7% |
Other | 20 | 11% |
Unknown | 47 | 26% |
Readers by discipline | Count | As % |
---|---|---|
Immunology and Microbiology | 41 | 23% |
Biochemistry, Genetics and Molecular Biology | 33 | 19% |
Agricultural and Biological Sciences | 20 | 11% |
Medicine and Dentistry | 19 | 11% |
Engineering | 3 | 2% |
Other | 13 | 7% |
Unknown | 49 | 28% |