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X Demographics
Mendeley readers
Attention Score in Context
| Title |
miR-155 is involved in Alzheimer’s disease by regulating T lymphocyte function
|
|---|---|
| Published in |
Frontiers in Aging Neuroscience, April 2015
|
| DOI | 10.3389/fnagi.2015.00061 |
| Pubmed ID | |
| Authors |
Juhyun Song, Jong Eun Lee |
| Abstract |
Alzheimer's disease (AD) is considered the most common cause of sporadic dementia. In AD, adaptive and innate immune responses play a crucial role in clearance of amyloid beta and maintenance of cognitive functions. In addition to other changes in the immune system, AD alters the T-cell responses that affect activation of glial cells, neuronal cells, macrophages, and secretion of pro-inflammatory cytokines. These changes in the immune system influence AD pathogenesis. Micro-RNA (miRNA)-155 is a multifunctional miRNA with a distinct expression profile. It is involved in diverse physiological and pathological mechanisms, such as immunity and inflammation. Recent studies indicate that miR-155 regulates T-cell functions during inflammation. In this article, we summarize recent studies describing the therapeutic potential of miR-155 via regulation of T cells in AD. Further, we propose that regulation of miR-155 might be a new protective approach against AD pathogenesis. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 89 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Denmark | 1 | 1% |
| Austria | 1 | 1% |
| Unknown | 87 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 15 | 17% |
| Researcher | 14 | 16% |
| Student > Master | 10 | 11% |
| Student > Bachelor | 9 | 10% |
| Student > Doctoral Student | 5 | 6% |
| Other | 15 | 17% |
| Unknown | 21 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 21 | 24% |
| Biochemistry, Genetics and Molecular Biology | 13 | 15% |
| Medicine and Dentistry | 10 | 11% |
| Neuroscience | 6 | 7% |
| Immunology and Microbiology | 4 | 4% |
| Other | 10 | 11% |
| Unknown | 25 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 May 2015.
All research outputs
#3,560,869
of 26,184,649 outputs
Outputs from Frontiers in Aging Neuroscience
#1,695
of 5,640 outputs
Outputs of similar age
#42,941
of 280,286 outputs
Outputs of similar age from Frontiers in Aging Neuroscience
#23
of 64 outputs
Altmetric has tracked 26,184,649 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,640 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.5. This one has gotten more attention than average, scoring higher than 67% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 280,286 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 64 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.