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Inducible and combinatorial gene manipulation in mouse brain

Overview of attention for article published in Frontiers in Cellular Neuroscience, April 2015
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Title
Inducible and combinatorial gene manipulation in mouse brain
Published in
Frontiers in Cellular Neuroscience, April 2015
DOI 10.3389/fncel.2015.00142
Pubmed ID
Authors

Godwin K. Dogbevia, Ricardo Marticorena-Alvarez, Melanie Bausen, Rolf Sprengel, Mazahir T. Hasan

Abstract

We have deployed recombinant adeno-associated viruses equipped with tetracycline-controlled genetic switches to manipulate gene expression in mouse brain. Here, we show a combinatorial genetic approach for inducible, cell type-specific gene expression and Cre/loxP mediated gene recombination in different brain regions. Our chemical-genetic approach will help to investigate 'when', 'where', and 'how' gene(s) control neuronal circuit dynamics, and organize, for example, sensory signal processing, learning and memory, and behavior.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 74 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 1%
Unknown 73 99%

Demographic breakdown

Readers by professional status Count As %
Researcher 24 32%
Student > Master 11 15%
Student > Ph. D. Student 10 14%
Student > Bachelor 8 11%
Student > Doctoral Student 4 5%
Other 4 5%
Unknown 13 18%
Readers by discipline Count As %
Neuroscience 21 28%
Agricultural and Biological Sciences 14 19%
Biochemistry, Genetics and Molecular Biology 13 18%
Medicine and Dentistry 4 5%
Immunology and Microbiology 2 3%
Other 5 7%
Unknown 15 20%