Title |
Simulation of cholinergic and noradrenergic modulation of behavior in uncertain environments
|
---|---|
Published in |
Frontiers in Computational Neuroscience, January 2012
|
DOI | 10.3389/fncom.2012.00005 |
Pubmed ID | |
Authors |
Michael C. Avery, Douglas A. Nitz, Andrea A. Chiba, Jeffrey L. Krichmar |
Abstract |
Attention is a complex neurobiological process that involves rapidly and flexibly balancing sensory input and goal-directed predictions in response to environmental changes. The cholinergic and noradrenergic systems, which have been proposed to respond to expected and unexpected environmental uncertainty, respectively, play an important role in attention by differentially modulating activity in a multitude of cortical targets. Here we develop a model of an attention task that involves expected and unexpected uncertainty. The cholinergic and noradrenergic systems track this uncertainty and, in turn, influence cortical processing in five different, experimentally verified ways: (1) nicotinic enhancement of thalamocortical input, (2) muscarinic regulation of corticocortical feedback, (3) noradrenergic mediation of a network reset, (4) locus coeruleus (LC) activation of the basal forebrain (BF), and (5) cholinergic and noradrenergic balance between sensory input and frontal cortex predictions. Our results shed light on how the noradrenergic and cholinergic systems interact with each other and a distributed set of neural areas, and how this could lead to behavioral adaptation in the face of uncertainty. |
X Demographics
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 4 | 6% |
Switzerland | 1 | 1% |
Germany | 1 | 1% |
Canada | 1 | 1% |
Brazil | 1 | 1% |
Unknown | 59 | 88% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 23 | 34% |
Researcher | 12 | 18% |
Student > Master | 7 | 10% |
Student > Bachelor | 5 | 7% |
Student > Doctoral Student | 5 | 7% |
Other | 11 | 16% |
Unknown | 4 | 6% |
Readers by discipline | Count | As % |
---|---|---|
Psychology | 15 | 22% |
Agricultural and Biological Sciences | 14 | 21% |
Neuroscience | 12 | 18% |
Computer Science | 7 | 10% |
Engineering | 3 | 4% |
Other | 10 | 15% |
Unknown | 6 | 9% |