Title |
Lactate Effectively Covers Energy Demands during Neuronal Network Activity in Neonatal Hippocampal Slices
|
---|---|
Published in |
Frontiers in Neuroenergetics, January 2011
|
DOI | 10.3389/fnene.2011.00002 |
Pubmed ID | |
Authors |
Anton Ivanov, Marat Mukhtarov, Piotr Bregestovski, Yuri Zilberter |
Abstract |
Although numerous experimental data indicate that lactate is efficiently used for energy by the mature brain, the direct measurements of energy metabolism parameters during neuronal network activity in early postnatal development have not been performed. Therefore, the role of lactate in the energy metabolism of neurons at this age remains unclear. In this study, we monitored field potentials and contents of oxygen and NAD(P)H in correlation with oxidative metabolism during intense network activity in the CA1 hippocampal region of neonatal brain slices. We show that in the presence of glucose, lactate is effectively utilized as an energy substrate, causing an augmentation of oxidative metabolism. Moreover, in the absence of glucose lactate is fully capable of maintaining synaptic function. Therefore, during network activity in neonatal slices, lactate can be an efficient energy substrate capable of sustaining and enhancing aerobic energy metabolism. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 4 | 4% |
Portugal | 1 | 1% |
Germany | 1 | 1% |
Finland | 1 | 1% |
Netherlands | 1 | 1% |
Venezuela, Bolivarian Republic of | 1 | 1% |
Japan | 1 | 1% |
Unknown | 82 | 89% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 20 | 22% |
Researcher | 13 | 14% |
Student > Master | 13 | 14% |
Professor | 10 | 11% |
Student > Bachelor | 9 | 10% |
Other | 14 | 15% |
Unknown | 13 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 29 | 32% |
Neuroscience | 19 | 21% |
Biochemistry, Genetics and Molecular Biology | 10 | 11% |
Medicine and Dentistry | 9 | 10% |
Psychology | 2 | 2% |
Other | 7 | 8% |
Unknown | 16 | 17% |