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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Alpha-synuclein Toxicity in the Early Secretory Pathway: How It Drives Neurodegeneration in Parkinsons Disease
|
|---|---|
| Published in |
Frontiers in Neuroscience, November 2015
|
| DOI | 10.3389/fnins.2015.00433 |
| Pubmed ID | |
| Authors |
Ting Wang, Jesse C. Hay |
| Abstract |
Alpha-synuclein is a predominant player in the pathogenesis of Parkinson's Disease. However, despite extensive study for two decades, its physiological and pathological mechanisms remain poorly understood. Alpha-synuclein forms a perplexing web of interactions with lipids, trafficking machinery, and other regulatory factors. One emerging consensus is that synaptic vesicles are likely the functional site for alpha-synuclein, where it appears to facilitate vesicle docking and fusion. On the other hand, the dysfunctions of alpha-synuclein are more dispersed and numerous; when mutated or over-expressed, alpha-synuclein affects several membrane trafficking and stress pathways, including exocytosis, ER-to-Golgi transport, ER stress, Golgi homeostasis, endocytosis, autophagy, oxidative stress, and others. Here we examine recent developments in alpha-synuclein's toxicity in the early secretory pathway placed in the context of emerging themes from other affected pathways to help illuminate its underlying pathogenic mechanisms in neurodegeneration. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 17% |
| Unknown | 5 | 83% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 83% |
| Scientists | 1 | 17% |
Mendeley readers
The data shown below were compiled from readership statistics for 148 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| Switzerland | 1 | <1% |
| Unknown | 146 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 27 | 18% |
| Student > Master | 25 | 17% |
| Researcher | 22 | 15% |
| Student > Bachelor | 18 | 12% |
| Student > Doctoral Student | 9 | 6% |
| Other | 23 | 16% |
| Unknown | 24 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 34 | 23% |
| Agricultural and Biological Sciences | 29 | 20% |
| Biochemistry, Genetics and Molecular Biology | 28 | 19% |
| Medicine and Dentistry | 10 | 7% |
| Immunology and Microbiology | 5 | 3% |
| Other | 14 | 9% |
| Unknown | 28 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 14. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 December 2015.
All research outputs
#2,485,750
of 25,374,917 outputs
Outputs from Frontiers in Neuroscience
#1,510
of 11,541 outputs
Outputs of similar age
#34,112
of 293,249 outputs
Outputs of similar age from Frontiers in Neuroscience
#17
of 152 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 11,541 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.9. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 293,249 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 152 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.