Title |
Protective Mechanism of Hydrogen Sulfide against Chemotherapy-Induced Cardiotoxicity
|
---|---|
Published in |
Frontiers in Pharmacology, January 2018
|
DOI | 10.3389/fphar.2018.00032 |
Pubmed ID | |
Authors |
Shuxu Du, Yaqian Huang, Hongfang Jin, Tianyou Wang |
Abstract |
Over the past few decades, the number of long term survivors of childhood cancers has been increased exponentially. However, among these survivors, treatment-related toxicity, especially cardiotoxicity, is becoming the essential cause of morbidity and mortality. Thus, preventing the treatment-related adverse effects is important to increase the event free survival during the treatment of cancer in children and adolescents. Accumulating evidence has demonstrated that hydrogen sulfide (H2S) exerts a protective role on cardiomyocytes through a variety of mechanisms. Here, we mainly reviewed the cardioprotective role of H2S in the chemotherapy, and emphatically discussed the possible mechanisms. |
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Country | Count | As % |
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Germany | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 67% |
Science communicators (journalists, bloggers, editors) | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 23 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 5 | 22% |
Student > Master | 4 | 17% |
Researcher | 2 | 9% |
Lecturer | 1 | 4% |
Student > Doctoral Student | 1 | 4% |
Other | 4 | 17% |
Unknown | 6 | 26% |
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Biochemistry, Genetics and Molecular Biology | 3 | 13% |
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Chemistry | 2 | 9% |
Nursing and Health Professions | 1 | 4% |
Other | 5 | 22% |
Unknown | 6 | 26% |