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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Skeletal Muscle Inflammation Following Repeated Bouts of Lengthening Contractions in Humans
|
|---|---|
| Published in |
Frontiers in Physiology, January 2016
|
| DOI | 10.3389/fphys.2015.00424 |
| Pubmed ID | |
| Authors |
Michael R. Deyhle, Amanda M. Gier, Kaitlyn C. Evans, Dennis L. Eggett, W. Bradley Nelson, Allen C. Parcell, Robert D. Hyldahl |
| Abstract |
Skeletal muscle responds to exercise-induced damage by orchestrating an adaptive process that protects the muscle from damage by subsequent bouts of exercise, a phenomenon called the repeated bout effect (RBE). The mechanisms underlying the RBE are not understood. We hypothesized that an attenuated inflammation response following a repeated bout of lengthening contractions (LC) would be coincidental with a RBE, suggesting a potential relationship. Fourteen men (n = 7) and women (n = 7) completed two bouts of lengthening contractions (LC) separated by 28 days. Muscle biopsies were taken before the first bout (B1) from the non-exercised leg, and from the exercised leg 2- and 27-d post-B1 and 2-d following the second bout (B2). A 29-plex cytokine array identified alterations in inflammatory cytokines. Immunohistochemistry quantified inflammatory cell infiltration and major histocompatibility complex class 1 (MHC-1). Muscle soreness was attenuated in the days following B2 relative to B1, indicating a RBE. Intramuscular monocyte chemoattractant protein (MCP1) and interferon gamma-induced protein 10 (IP10) increased following B2 relative to the pre-exercise sample (7-52 and 11-36 pg/ml, respectively p < 0.05). Interleukin 4 (IL4) decreased (26-13 pg/ml, p < 0.05) following B2 relative to the pre-exercise sample. Infiltration of CD68(+) macrophages and CD8(+) T-cells were evident following B2, but not B1. Moreover, CD8(+) T-cells were observed infiltrating apparently necrotic muscle fibers. No changes in MHC-1 were found. We conclude that inflammation is not attenuated following a repeated bout of LC and that CD8(+) T-cells may play a role in muscle adaptation following LC. Moreover, it appears that the muscle or the immune system becomes sensitized to an initial bout of damaging exercise such that inflammatory cell infiltration into the muscle is enhanced upon a repeated bout of damaging exercise. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 15 | 18% |
| United States | 8 | 10% |
| Australia | 2 | 2% |
| Germany | 1 | 1% |
| Denmark | 1 | 1% |
| South Africa | 1 | 1% |
| India | 1 | 1% |
| Taiwan | 1 | 1% |
| Canada | 1 | 1% |
| Other | 3 | 4% |
| Unknown | 49 | 59% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 41 | 49% |
| Scientists | 36 | 43% |
| Practitioners (doctors, other healthcare professionals) | 5 | 6% |
| Science communicators (journalists, bloggers, editors) | 1 | 1% |
Mendeley readers
The data shown below were compiled from readership statistics for 147 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | <1% |
| Unknown | 146 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 25 | 17% |
| Student > Bachelor | 22 | 15% |
| Student > Master | 20 | 14% |
| Researcher | 16 | 11% |
| Professor | 9 | 6% |
| Other | 32 | 22% |
| Unknown | 23 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Sports and Recreations | 39 | 27% |
| Medicine and Dentistry | 19 | 13% |
| Biochemistry, Genetics and Molecular Biology | 13 | 9% |
| Nursing and Health Professions | 11 | 7% |
| Agricultural and Biological Sciences | 9 | 6% |
| Other | 22 | 15% |
| Unknown | 34 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 158. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 February 2021.
All research outputs
#254,255
of 25,129,395 outputs
Outputs from Frontiers in Physiology
#136
of 15,439 outputs
Outputs of similar age
#4,398
of 407,163 outputs
Outputs of similar age from Frontiers in Physiology
#4
of 133 outputs
Altmetric has tracked 25,129,395 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 15,439 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.0. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 407,163 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 133 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.