Title |
Epstein–Barr Virus-Induced Metabolic Rearrangements in Human B-Cell Lymphomas
|
---|---|
Published in |
Frontiers in Microbiology, June 2018
|
DOI | 10.3389/fmicb.2018.01233 |
Pubmed ID | |
Authors |
Pier P. Piccaluga, Alessandra Weber, Maria R. Ambrosio, Yonis Ahmed, Lorenzo Leoncini |
Abstract |
Tumor metabolism has been the object of several studies in the past, leading to the pivotal observation of a consistent shift toward aerobic glycolysis (so-called Warburg effect). More recently, several additional investigations proved that tumor metabolism is profoundly affected during tumorigenesis, including glucose, lipid and amino-acid metabolism. It is noticeable that metabolic reprogramming can represent a suitable therapeutic target in many cancer types. Epstein-Barr virus (EBV) was the first virus linked with cancer in humans when Burkitt lymphoma (BL) was described. Besides other well-known effects, it was recently demonstrated that EBV can induce significant modification in cell metabolism, which may lead or contribute to neoplastic transformation of human cells. Similarly, virus-induced tumorigenesis is characterized by relevant metabolic abnormalities directly induced by the oncoviruses. In this article, the authors critically review the most recent literature concerning EBV-induced metabolism alterations in lymphomas. |
X Demographics
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Geographical breakdown
Country | Count | As % |
---|---|---|
Italy | 1 | 20% |
Unknown | 4 | 80% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 5 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 42 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 8 | 19% |
Researcher | 7 | 17% |
Other | 6 | 14% |
Student > Master | 4 | 10% |
Student > Doctoral Student | 3 | 7% |
Other | 6 | 14% |
Unknown | 8 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 9 | 21% |
Medicine and Dentistry | 8 | 19% |
Agricultural and Biological Sciences | 6 | 14% |
Immunology and Microbiology | 6 | 14% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
Other | 4 | 10% |
Unknown | 8 | 19% |